HIV/AIDS

HIV is the virus that causes AIDS.
Like other viruses, HIV multiplies by entering and overtaking the metabolic
machinery of human cells. But HIV is unique because it kills the very
cells that are meant to fight infection — T cells, a type of white
blood cell. Over the course of several years, HIV systematically destroys
these cells, dismantling the immune system. Eventually, the body is left
defenseless against a host of deadly opportunistic infections and cancers.HIV is spread through blood, semen, breast milk and vaginal fluid, including
menstrual fluid. People who contract HIV may remain healthy for many years
and, without testing, may be unaware that they carry the virus. Indeed,
the disease has spread so far and so fast precisely because many people
are unaware that they are infected and so fail to take precautions to
prevent spreading it to others.

HIV is also unusual because it is virtually 100% fatal. In the vast majority
of cases worldwide, HIV leads to death within five to 10 years of infection.

Each HIV particle is composed of an outer layer studded with proteins
known as gp120, and a core that houses its genetic information. In a two-step
process, HIV uses gp120 to bind to a pair of receptors on the surface
of T cells, allowing the virus to enter the cell.

Once inside, the HIV virus fuses with the cell’s genetic machinery
and begins to multiply, producing thousands of progeny. In time, the T
cell bursts like a seedpod, scattering new HIV virus to infect and kill
other cells. The cycle is then repeated countless times. Click here
for more information about the HIV infection process.